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Author

Vikrant Kumar

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Open access Sep 2026

Fragment-Based Discovery of BRD4-BD2 Selective Binders: Biophysical Validation and Structural Insights for Domain-Selective Inhibitor Design

BRD4, a member of the bromodomain and extra-terminal (BET) family of epigenetic readers, plays a central role in transcriptional regulation and is implicated in a wide spectrum of diseases. Although BRD4 inhibitors targeting both bromodomains have advanced into clinical studies, their development and therapeutic use ar...

Sriram Prakash Baskaran, Yashini Vidhya Subramani, S. Bairy et al. · 0 citations

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