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Author

Vincent Vanoosthuyse

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Open access Sep 2026

The rapid delivery of RNase H variants reveals distinct classes of RNA:DNA hybrids

Multiple lines of evidence suggest that RNase H1-sensitive RNA:DNA hybrids (thereafter referred to as ‘hybrids’) could disrupt the stability and restart of stalled replication forks. The prolonged over-expression of RNase H1 is the most popular method to manipulate hybrids in situ but it cannot discriminate between dir...

Amandine Basille, Yara Bawadi, Yea-Lih Lin et al. · 0 citations

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