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Author

Vinod P. Balachandran

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Open access Sep 2026

Neoantigen-reactive CD8+ T cell engagement marks exceptional survivors of pancreatic cancer

Pancreatic cancer (PC) is largely refractory to immune checkpoint blockade (ICB), although homologous recombination-deficient (HRD) tumors may derive benefit. In the POLAR trial of maintenance pembrolizumab plus olaparib after platinum-based chemotherapy for metastatic PC, responses remained heterogeneous. To define de...

M. Hilmi, J. Schoenfeld, Wilson H. McKerrow et al. · 0 citations
Jul 2026

Abstract PR004: enFoldX: AI classification of AlphaFold3-derived structural ensembles enables T cell specificity prediction

An ensemble approach (enFoldX) that leverages structure prediction models such as AlphaFold3 to build sensitive binding predictors and outperforms the current co-folding methods which rely on predictions from the single top ranked structure.

O. Lyudovyk, Jonathan A. Levine, M. Pathil et al. · 0 citations
Jul 2026

Abstract A028: enFoldX: AI classification of AlphaFold3-derived structural ensembles enables T cell specificity prediction

An ensemble approach (enFoldX) that leverages structure prediction models such as AlphaFold3 to build sensitive binding predictors and outperforms the current co-folding methods which rely on predictions from the single top ranked structure.

O. Lyudovyk, Jonathan A. Levine, M. Pathil et al. · 0 citations

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