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Author

Vishanna Balkaran

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Open access Aug 2026

pAc/Emm55 increases anti-melanoma immunity via TLR2 signaling in dendritic cells and improves checkpoint blockade efficacy

Background pAc/Emm55 (IFx-Hu2.0) is a plasmid DNA therapy encoding a Streptococcus pyogenes-derived bacterial gene. It shows anti-tumor activity in preclinical models, but the mechanisms of anti-melanoma immunity and additive effects with immune checkpoint blockade remain unclear. Methods B16 melanoma tumor-bearing mic...

T. H. N. Le, Q. T. Nguyen, Youngchul Kim et al. · 0 citations

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