Vivek Sharma

Design to Neuroprotection: A Blood Brain Barrier Permeable Selective HDAC3 Inhibitor Active against Chemical and Viral Insults

Neuronal loss in neurodegenerative diseases is mediated by oxidative stress, neuroinflammation, and epigenetic dysregulation, with histone deacetylase 3 (HDAC3) playing a central role in inflammatory signaling and neuronal damage. We...

Discovery of cyanocarbonimidodithioates as novel non-hydroxamate zinc-binding groups for selective HDAC8 inhibition: Design, synthesis, biological evaluation, anticancer activity, and in silico studies.

Exploration of non-hydroxamate based quinoline analogues as HDAC8 inhibitors

Novel non-hydroxamate-based quinoline analogues were designed and explored as HDAC8-selective inhibitors that exhibit nanomolar HDAC8 enzymatic inhibition and establish these compounds as promising HDAC8 modulators with potential for therapeutic development in neuroblastoma.