Author

Vladimir A. Martínez-Rojas

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Open access Sep 2026

Age-related electrophysiological changes in layer 5 pyramidal cells and interneurons of the rat medial prefrontal cortex.

Overall, aging differentially disrupts excitability and ionic mechanisms in pyramidal and interneuron populations, leading to impaired synaptic integration and altered short-term plasticity in mPFC microcircuits, suggesting that disrupted synaptic integration and intrinsic neuronal function in the aged neocortex may co...

Vladimir A. Martínez-Rojas, Diana A. Rosas-García, Gabriela Rocha-Botello et al. · Mechanisms of Ageing and Dev... · 0 citations

Jul 2026

Chronic pain induces cell type-specific alterations in the intrinsic excitability of spinal cord lamina II circuits in female rats.

It is demonstrated that chronic pain induces firing pattern-dependent adaptations in intrinsic excitability, with selective enhancement of responsiveness in IB neurons, which may contribute to persistent amplification of nociceptive signaling by reshaping microcircuit dynamics within the superficial dorsal horn, thereb...

Lucero Guzmán-Pérez, Amayrani Perez-Barragan, Guadalupe Raya-Tafolla et al. · Neuroscience Letters · 0 citations