Open access
Sep 2026
APOE4 differentially alters lipid composition in extracellular vesicles from hiPSC-derived neurons of Alzheimer’s disease patients
Background The Apolipoprotein E4 (APOE4) is the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), but the cellular mechanisms by which it increases vulnerability remain poorly understood. Lipids play a crucial role in membrane organization, vesicle trafficking, and inflammatory signaling in...
Marios G. Krokidis, Ram Sagar, Maja Mustapić et al.
· Frontiers in Pharmacology · 0 citations