Vy M. Dong

Modular synthesis of α-tertiary amino acids from C–H feedstocks

Both linear and cyclic unnatural amino acids (UAAs) play a central role in drug discovery but remain challenging to access from feedstocks. Inspired by terpene biosynthesis, we designed a simple and unified olefin precursor that can be diverged into constrained cyclic motifs, including prolines, azepanes, carbamates, e...