W. Al-Megrin

Targeting Neuroinflammation and Monoamine Dysregulation: Galangins Multifacedted Neuroprotective Role against LPS-Induced Brain Injury

Galangin had neuroprotection against LPS-induced brain injury by modulating neurochemical, inflammatory and apoptotic mechanisms, reducing oxidative and inflammatory damage and regulating apoptotic pathways.

Combined effects of dietary ellagic acid and Bacillus coagulans on growth performance, antioxidant and immune responses, intestinal health, and resistance to Streptococcus agalactiae in striped catfish

Network pharmacology-guided subtractive proteomics coupled with molecular docking and molecular dynamics simulation identifies Nigella sativa as a potential anti-sepsis therapeutic

The findings suggest that N. sativa may provide dual therapeutic benefits by modulating host immune responses and targeting pathogen proteins, supporting its potential for future anti-sepsis drug development based on computational predictions that require experimental validation.

Therapeutic Antitoxoplasmosis Potential of Garcinia cambogia: Evidence From In Silico and In Vivo Studies

Toxoplasma gondii, an opportunistic protozoan, is widely prevalent and poses potential health risks. Its treatment remains challenging with several side effects, urging the exploration of new, safe, and efficient drugs. We aimed to explore the therapeutic efficacy of the medicinal plant Garcinia cambogia (GC) against b...

Prodigiosin-conjugated silver nanoparticles target neuroimmune dysregulation and pro-inflammatory cytokines TNF-α, IL-1β/NF-kB pathways in an autistic model of rat pups

PG-AgNPs demonstrated significant neuroprotective, anti-inflammatory, and antioxidant effects in the autistic rat model, suggesting their potential as a nanotherapeutic approach for ASD.

Harnessing an endophytic Bacillus strain closely related to Bacillus velezensis for biocontrol of twig blight in bayberry caused by Pestalotiopsis versicolor

Findings suggest that Bay9 has potential as a biocontrol agent against P. versicolor under laboratory, detached-leaf, and semi-controlled greenhouse conditions, and further studies are required to elucidate the underlying molecular mechanisms and to validate its efficacy under field conditions before practical applicat...