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W. Blankenfeldt

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Review Open access Sep 2026

Phenazine Biosynthesis Inhibitors as Pseudomonas aeruginosa Antivirulence Agents

Phenazines are redox-active secondary metabolites produced by a variety of bacteria, including Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen associated with severe, often chronic infections and particularly notorious for its multiple resistance mechanisms. A major contributor to P. aeruginosa virulen...

Maria Handke, Janosch Baumgarten, Marie Thiemann et al. · 0 citations
Open access Aug 2026

Synthesis and Activity-Based Protein Profiling Identifies Aldo-Keto Reductase 1C3 as Target Protein of Myxoglucamides.

The identification of aldo-keto reductase 1C3 (AKR1C3) as the primary target of myxoglucamides in human cells implies that the search for targets of natural products is rewarding even in the absence of an initial phenotypic activity.

Thomas Siemon, Vivek K. Mishra, Mingming Zhao et al. · 0 citations

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