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W. Britton

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Open access Aug 2026

Development of macrocyclic peptide inhibitors of Mycobacterium tuberculosis MurF via mRNA display with genetic reprogramming.

The development of new antibacterials for Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains critical due to the continued global burden of disease and the emergence of multi-drug resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains. The MurF enzyme, which catalyses the AT...

Patrick W. Carlos, Charlotte Franck, Caitlin E. Clarke-Shepperson et al. · 0 citations
Open access Jul 2026

Genetic dissection of persiathiacin biosynthesis defines hierarchical P450 oxidations and reveals a more potent antitubercular intermediate

The results define the enzymatic logic and temporal organization of persiathiacin biosynthesis, providing a conceptual framework for rational diversification of complex thiopeptide natural products.

F. A. Sumang, Maxwell T. Stevens, W. Britton et al. · 0 citations

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