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Author

W. El Yakoubi

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Open access Sep 2026

The CENP-A chaperone complex spatially organizes centromeres

Centromeres, defined by CENP-A–containing nucleosomes, direct kinetochore assembly for spindle attachment. In mitosis, CENP-A and the constitutive centromere-associated network (CCAN) of the inner kinetochore are arranged into bipartite subdomains within clearings of chromatin. However, less is known about their archit...

Hindol Gupta, Julian Haase, Yi-Cong Wu et al. · 0 citations
Open access Aug 2026

Set mediates chromosome alignment and Cohesin cleavage independently of direct PP2A-B56-binding in oocyte meiosis

Set promotes cohesion removal in mitosis by evicting phosphorylated Histone H1 and counteracting Sgo1. In addition, Set promotes chromosome alignment by counteracting Aurora B activation. The underlying molecular mechanisms through which Set performs these activities remain insufficiently characterized, but roles of Se...

Leonor Keating, Arianna Esposito Verza, W. El Yakoubi et al. · 0 citations

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