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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

W. Foulkes

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Review Sep 2026

Balancing benefits, costs, and harms: policy implications of expanding cancer susceptibility testing from genetics clinics to the general population.

Cancer susceptibility testing is rapidly advancing beyond specialist genetics clinics into routine oncology and population-level genomics initiatives. This expansion positions germline pathogenic variants in cancer susceptibility genes and polygenic risk scores as crucial tools for precision prevention, surveillance, a...

Clare Turnbull, Sandra Perdomo, S. Domchek et al. · 1 citation
Review Sep 2026

Germline predisposition and the pattern of breast cancer metastasis.

The synthesis of data from mouse models and human-derived materials supports a speculative model where the crosstalk between BC cells and the microenvironment defines the metastasis pattern in carriers of GPVs in BCSGs.

I. Elkholi, W. Foulkes · 0 citations
Open access Aug 2026

HMGA2 is a highly sensitive marker for DICER1-related tumours.

AIMS DICER1 is a microRNA biogenesis enzyme that, when mutated, results in a rewiring of the transcriptome. Germline pathogenic variants (PVs) in DICER1 result in DICER1-related tumour predisposition (DRTP) characterized by 30 or more different, generally rare, paediatric or adolescent-onset tumours. One of these, pitu...

P. Thorner, Anne-Laure Chong, Naciba Benlimane et al. · 0 citations

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