Open access
Sep 2026
Colloidal protein stability and surface coverage by trehalose: bridging molecular dynamics and experimental work.
The aim of this study was to assess to what extent a simulated trehalose monolayer can predict the minimum molar trehalose to protein ratios required to preserve the colloidal stability of lyophilized lactate dehydrogenase, catalase, and β-galactosidase. We employed an iterative molecular dynamics (MD) approach to quan...
D. Zillen, V. Adupa, K. Nguyen et al.
· European journal of pharmace... · 0 citations