Author

W. Jin

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Open access Sep 2026

Tumor-derived MG53 aggravates gastrointestinal cancer cachexia related muscle atrophy by inhibiting the TLR4/PI3K/AKT/FOXO3a signaling pathway

Background Cancer cachexia is a multisystem syndrome characterized by progressive skeletal muscle atrophy, anorexia, and weight loss, imposing a substantial global health burden. Gastrointestinal cancer cachexia is highly prevalent, yet its pathogenesis remains poorly understood, and there is currently a lack of effect...

Yong-Fei Wang, Yuan-Yuan Xin, Si-Yuan Wang et al. · Frontiers in Oncology · 0 citations

Review Open access Sep 2026

Heterogeneity in cancer: molecular mechanisms and therapeutic strategies

The Holistic Integrative Tumor Ecosystem Theory (HITET) is proposed, a five-dimensional framework connecting these scales through functional interfaces that synthesizes how genetic alterations, cellular plasticity, metabolic programs, immune and stromal interactions, spatial gradients, organ-specific environments, micr...

Yong-Lin He, Liang Niu, Yan-Ming Ren et al. · Signal Transduction and Targ... · 0 citations