Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global public health burden with progressive hepatic and cardiometabolic consequences. Insulin resistance is central to MASLD pathogenesis, and the triglyceride-glucose (TyG) index is a practical surrogate marker for insulin resistance...
S. Kang, N. Zhang, W. Chen et al.· European Heart Journal· 0 citations
Nonalcoholic fatty liver disease (NAFLD), now termed metabolic dysfunction-associated steatotic liver disease (MASLD), is closely linked to insulin resistance and chronic inflammation, serving as a key driver of cardiovascular-kidney-metabolic (CKM) syndrome. However, its precise role in CKM progression remains p...
W. Li, W. Chen, R. Huang· European Heart Journal· 0 citations
Accelerated biological aging was robustly associated with advanced CKM across all populations, with PhenoAge consistently outperforming KDMAge, and PhenoAge demonstrated superior risk stratification capability compared to KDMAge, highlighting its potential utility in early risk assessment.
Y. Chen, W. Li, W. Chen et al.· European Heart Journal· 0 citations
The systemic inflammation response index (SIRI) was associated with higher risk of mortality in individuals with Cardiovascular-Kidney-Metabolic (CKM) syndrome stages 0–2. However, the long-term effect of high SIRI on all-cause mortality risk remains unclear in middle-aged and elderly individuals with CKM syndrom...
X. Liu, W. Chen, Y. Chen et al.· European Heart Journal· 0 citations
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