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Open access 2026

Predictors of four versus six cycles of adjuvant docetaxel–cyclophosphamide in hormone receptor-positive early breast cancer

Introduction: Docetaxel and cyclophosphamide (TC) are a commonly used anthracycline-free regimen for hormone receptor-positive (HR+) early-stage breast cancer. Although typically administered for four to six cycles, the optimal number remains uncertain. Objective: To identify clinical and pathological factors associat...

W. Lima, Rafaela Lopes da Silva Naves, R. Bonadio et al. · 0 citations
Open access 2026

The relationship between tumor-infiltrating lymphocytes, pathologic complete response, and event-free survival in patients with early-stage triple-negative breast cancer treated with the KEYNOTE-522 regimen in a real-world scenario

Introduction: Tumor-infiltrating lymphocytes (TILs) are established prognostic and predictive biomarkers in early-stage triple-negative breast cancer (eTNBC). The addition of pembrolizumab to neoadjuvant chemotherapy (NAC) improves outcomes, as demonstrated in the KEYNOTE-522 trial. The role of TILs in this setting war...

R. Bonadio, M. Monteiro, W. Lima et al. · 0 citations
Open access 2026

Papillary breast cancer: therapeutic and prognostic real-world data on a rare histologic type

Introduction: Papillary carcinoma is classified as a special subtype of breast neoplasm with an estimated incidence of 0.5% to 1.7% of all invasive breast carcinomas. Due to its rarity, treatment for these tumors is generally based on extrapolation from data on non-special tumor types. Objective: This study aimed to d...

W. Lima, Iara Garcia Nakashima, Y. Reis et al. · 0 citations

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