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Open access Aug 2026

A unified framework for local-ancestry-aware genetic association analysis across biobanks

Biobanks increasingly include individuals with admixed genomes, yet conventional genome-wide association study frameworks either exclude participants who cannot be confidently assigned to a discrete ancestry group or ignore ancestry-specific effects. We present FELIX, a scalable framework for local-ancestry-aware genet...

L. Hu, T. Tan, K. Yuan et al. · 0 citations
Open access Aug 2026

Estimating the contribution of coding mutations to autism

It is found that damaging de novo single-nucleotide variants and frameshift indels explain 3.4% (95% CI: 2.1% - 4.7%) of autism variance on the observed scale.

A. Nadig, J. Fu, F. Satterstrom et al. · 0 citations
Open access Aug 2026

Rare variation illuminates the distinct and pleiotropic genetic architecture of autism across neuropsychiatric traits

This study finds that rare variants across hundreds of genes contribute to autism with variable phenotypic outcomes, and clusters them based on association evidence from large-scale studies of developmental disorders, schizophrenia, bipolar disorder, and epilepsy.

F. Satterstrom, C. Auwerx, J.-M. Fu et al. · 1 citation

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