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Author

W. Pezeshkian

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Open access Sep 2026

Presynaptic accumulation of APP-CTFβ may contribute to synaptic dysfunction in Alzheimer’s disease

It is shown that endogenous APP and its proteolytic C-terminal fragments (APP-CTFs), the precursors of amyloid-β (Aβ), are enriched at excitatory synapses, and that APP processing generates functionally distinct intermediates at the synapse, i.e. presynaptic APP-CTFβ, which can accumulate in the active zone of excitato...

Akshay Kapadia, Fabian Schuhmann, Ezgi Daskin et al. · 0 citations

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