W. R. C. N. Silva

Regioselective N ‐Benzotriazole Substitution Under Mechanochemical Conditions

Here, we present a simple and efficient method for synthesizing substituted benzotriazoles under mechanochemical conditions. Under optimal conditions, the coupling between 1,2,3‐benzotriazole and benzyl bromide occurs with 99% conversion and 17:1 regioselectivity within 30 min of neat milling. Using density functiona...