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Author

W. Reinisch

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Clinical trial Open access Oct 2026

Safety and tolerability of anti-toll-like receptor 3, monoclonal antibody PRV-300 in patients with moderate-to-severe ulcerative colitis: a randomized phase 1B clinical trial (PULSE)

Abstract Background & Aims PRV-300 is a fully human IgG4κ monoclonal antibody that binds the extracellular domain of human toll-like receptor 3, which is overexpressed in the inflamed colonic epithelium in patients with inflammatory bowel disease. This study aimed at proving its safety and efficacy in patients with ulc...

J. Pokryszka, Gail M. Comer, Camilla A. Richmond et al. · 0 citations

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