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Open access Jun 2026

Dual promoter architecture of NFE2L2 underlies isoform-specific translational control of NRF2

Transcription factor NRF2 (encoded by the NFE2L2 gene) is a central signalling hub that coordinates antioxidant, detoxification, anti-inflammatory and metabolic programmes to maintain cellular homeostasis, with broad relevance to degenerative diseases, chronic inflammation and cancer. NFE2L2 is transcribed from two pro...

A. Sznarkowska, Zuzanna Urban-Wójciuk, Alicja Dziadosz-Brzezińska et al. · 0 citations
Preprint Aug 2026

Can Unsupervised Methods Outperform Supervised Deep Learning When Ground Truth Is Sparse? A Case Study of Bronchovascular Bundle Segmentation in Low-Dose CT

Background Lung cancer remains the deadliest cancer worldwide because it is often diagnosed too late. Effective treatment depends on detection at an early screening stage. However, the growing number of patients and the limited number of radiologists lead to prolonged diagnostic waiting times. In very early stage lung...

A. Mrukwa, M. Socha, A. Suwalska et al. · 0 citations

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