Author

W. Seeley

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Open access Sep 2026

From neighborhoods to brain health: an outreach model linking health literacy, cognitive care, research, and the arts, in San Francisco

Traditional community outreach, research recruitment, and engagement strategies in aging neuroscience often fail to target and capture the diversity of structural and environmental conditions that shape the risk of age-related neurocognitive disorders (NCDs), including Alzheimer’s disease. In this manuscript, we descri...

S. Lanata, C. Windon, B. Tee et al. · Frontiers in Public Health · 0 citations

Open access Sep 2026

Tau‐associated neuronal loss in the intermediate nucleus of the human hypothalamus, a putative VLPO analog, in progressive supranuclear palsy and Alzheimer's disease

Sleep phenotypes differ in progressive supranuclear palsy (PSP) and Alzheimer's disease (AD). The human intermediate nucleus (IntN), a putative ventrolateral preoptic analog, promotes non‐rapid eye movement (NREM) sleep, but its disease‐specific vulnerability is unclear.

Shima Rastegar-Pouyani, Caroline Lew, F. Pereira et al. · Alzheimer's & Dementia · 0 citations

Open access Aug 2026

A neuronal CRISPRi screen identifies PQLC2 as a lysosomal pH regulator controlling tau homeostasis

Lysosomes make key contributions to the maintenance of cellular proteostasis, and their functional compromise has been linked to aging and neurodegenerative disease. A defining characteristic of lysosomes is their relative acidity compared to other subcellular compartments, a quality that enables the efficient breakdow...

Mackenzie Welch, Paul J. Sampognaro, Shun-Pan Shu et al. · bioRxiv · 0 citations