Saponins induce lipid-dependent structural heterogeneity and modulate membrane organization in phospholipid bilayers
Saponins are amphiphilic natural compounds whose membrane activity is commonly attributed to sterol complexation, whereas their effects on sterol-free membranes remain poorly understood. Here, we investigated how lipid packing governs the interaction of a Saponaria officinalis saponin extract with cholesterol-fre...