W. V. van Zyl

Synthesis, characterization, X-ray diffraction, in silico studies and in vitro biological evaluation of acylthiourea-derived thiazole-2-imines

A series of thiazole-2-imines (1a–1f) with unsubstituted aryl groups or aryl groups bearing methyl, methoxy, fluoro, or nitro substituents was designed using selected structural features of thiamine as inspiration. The compounds were synthesized from monosubstituted acylthioureas and para-substituted phenacyl bromides...