Endothelial senescence impairs efferocytosis and alters macrophage responses: insights into APP-CD74 signaling
Endothelial cell senescence contributes to vascular aging and chronic inflammation, yet its impact on endothelial–macrophage interactions remains poorly understood. Here, we combined functional assays, global proteomics, 3D co-culture spheroid models, and single-cell transcriptomics to elucidate how senescent end...