Multimodal MRI signatures and concurrent myelin remodeling alterations in the anterior cingulate cortex correlate with the antidepressant-like effects of 18β-glycyrrhetinic acid in CSDS mice.
BACKGROUND The anterior cingulate cortex (ACC) regulates emotion, and its dysfunction is associated with depression. 18β-glycyrrhetinic acid (18β-GA) exerts robust antidepressant effects; however, its roles in neural circuit remodeling of the ACC and underlying molecular mechanisms remain unclear. This study investigat...