Author

Wael M Elsaed

Taibah University

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Sep 2026

Nanovesicular Spanlastics Thermosensitive Gel for the Ocular Delivery of Voriconazole: Development, Ex Vivo Transcorneal Permeability, and In Vivo Evaluation in a Rabbit Model of Fungal Keratitis

Fungal keratitis remains a leading cause of corneal blindness and eye loss worldwide. Conventional antifungal preparations such as those of voriconazole (VCZ) are often limited by rapid precorneal drug loss and poor corneal penetration, leading to suboptimal therapeutic outcomes. This study aimed to address these limit...

G. Soliman, Ayman Salama, Mona Qushawy et al. · AAPS PharmSciTech · 0 citations

Open access Aug 2026

Buspirone attenuates cyclophosphamide-induced renal dysfunction in association with alterations in miR-205/EGLN2, Nrf2, and PERK/ATF4/CHOP signaling

Buspirone pretreatment mitigated CPA-induced renal dysfunction, accompanied by increased miR-205 expression, reduced EGLN2 expression, enhanced Nrf2-associated antioxidant defenses, and attenuation of ER stress, inflammation, and apoptosis, thereby preserving renal function and tissue integrity.

Ahmed M. El-Dessouki, A. Alrashidi, Mohammad I Jumaa et al. · Frontiers in Pharmacology · 1 citation