Open access
Aug 2026
Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy
ABSTRACT Despite advancements in immune checkpoint blockade (ICB) therapy, breast cancer shows limited response to anti‐PD1/PD‐L1 treatments, emphasizing the need for alternative ICB targets. Here, we reveal that endocrine therapeutics, specifically tamoxifen, create an immunosuppressive yet primed tumor microenvironme...
M. A. Aberin, Saurabh Singh, Soumya Chatterjee et al.
· Advancement of science · 0 citations