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Wallace Lung

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Review Open access Oct 2026

Safe host integration in islet tissue engineering for Type 1 Diabetes Mellitus: emerging technologies and a constraint-guided hybrid islet framework

Type 1 diabetes mellitus (T1DM) results from autoimmune destruction of pancreatic β cells and requires lifelong insulin replacement. Islet transplantation can restore endogenous insulin secretion, but donor scarcity, immune rejection, early graft loss, inadequate oxygen delivery, and fibrosis limit its application. Thi...

Wallace Lung · 0 citations

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