Author

Walter Kolch

3 papers indexed here

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Open access Oct 2026

Genomic and immune profiling characterizes immune heterogeneity and a TIGIT-associated subtype in intrahepatic cholangiocarcinoma

Background Intrahepatic cholangiocarcinoma (iCCA) is characterized by marked molecular and microenvironmental heterogeneity and moderate response to immunotherapy. We aimed to define the genomic and spatial determinants of immune checkpoint activity in iCCA and their association with clinical outcome. Methods We perfor...

A. Korosteleva, J. Reschke, Da-Wei Yi et al. · Hepatology Communications · 0 citations

Open access Oct 2026

SMAD3-driven cell state transitions underpin immunoresistance in bladder cancer

This work demonstrates that tumor cell state transitions control sensitivity to T cell killing, complementing established immune-intrinsic mechanisms of immunotherapy response.

Sarah Y. T. Robertson, J. Yang, Neil O. Carragher et al. · bioRxiv · 0 citations

Open access Oct 2026

Multiomic characterization of microsatellite-stable colorectal cancer reveals distinct biology and targetable vulnerabilities.

Microsatellite-stable (MSS) colorectal cancer (CRC) is a molecularly complex and clinically challenging disease subtype, lacking effective targeted therapies. Leveraging multiomic data from ∼2,000 tumor samples (including 316MSS CRCs not previously profiled) representing ∼4,500 molecular profiles and 195,246 single cel...

A. Sadanandam, A. O'Farrell, I. Miller et al. · Cancer Cell · 1 citation