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Author

Walter Rocchia

2 papers indexed here

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Preprint Sep 2026

Computational Insights into Mechanostability and Dissociation Dynamics of the Dengue Virus Envelope Protein Ectodomain Dimer Across pH and Temperature Gradients

Dengue virus (DENV) is an enveloped flavivirus of major public health importance. Its envelope (E) protein mediates viral entry through homodimer dissociation and subsequent membrane fusion, making it one of the principal targets for antiviral strategies. To investigate the molecular determinants of this process, we pe...

G. Ropón-Palacios, Luís G. F. Crespi, J. Rydzewski et al. · 0 citations
Open access Sep 2026

SCRIB inhibits PP1 phosphatase activity without blocking or structurally altering its active site.

Protein phosphorylation is a fundamental mechanism regulating cellular function, governed by the opposing actions of kinases and phosphatases. The substrate specificity and catalytic activity of protein phosphatase 1 (PP1), a major serine/threonine phosphatase, results from its interactions with more than 200 regulator...

Siba Alharbi, Amit Kumawat, Brandon Huntington et al. · 0 citations

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