Wan-Jie Gu

Lactate and lactylation in sepsis: regulation of immune-metabolic crosstalk and organ injury

Sepsis is a life−threatening organ dysfunction caused by a dysregulated host response to infection and remains a leading cause of death worldwide. Hyperlactatemia, a hallmark metabolic disorder in sepsis, has recently been recognized as an epigenetic modulator via lysine lactylation. This Review synthesizes the evolvin...