Oct 2026
Design and structure-activity relationship studies of marine-derived indolocarbazoles as potent PIM1 inhibitors for triple-negative breast cancer therapy.
P19 represents a promising PIM1-potent, PKC-sparing multi-kinase lead for further TNBC optimization and reduced PIM1-GBP1 association and GBP1 phosphorylation, suggesting that the PIM1/GBP1 axis may contribute to its cellular activity.
Yun Huang, Yi-Jun Ma, Jie-Bin Fang et al.
· Bioorganic chemistry (Print) · 0 citations