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Wan-Kun Wang

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Open access Aug 2026

KDM6A suppresses proliferation and epithelial-mesenchymal transition in prostate cancer cells.

BACKGROUND AND OBJECTIVE Prostate cancer is one of the most common male malignancies worldwide. KDM6A, a histone H3K27 demethylase, has been implicated in various cancers; however, its specific functions in prostate cancer remain controversial. This study aimed to investigate the regulatory role of KDM6A in castration-...

Yi-Xiu Ni, Yi-Jia Lin, Wan-Kun Wang et al. · Urologic oncology · 0 citations

Open access Aug 2026

Reprogramming PD-L1 endosomal recycling and lysosomal degradation via engineered exosome-based nanocomposites overcomes immune resistance in lung cancer brain metastasis

A pH-responsive nanocomposite engineered by functionalizing brain-metastatic tumor cell-derived exosomes with RGD peptides for targeted co-delivery of verteporfin and αPD-L1 successfully remodels the intracranial immunosuppressive microenvironment and triggers potent systemic anti-tumor immunity.

Xiujuan Hong, Xiao-Qi Wang, Wan-Kun Wang et al. · Materials Today Bio · 0 citations