Wan-Yi Tai

Site-selective acylation of human insulin to engineer a long-acting monovalent insulin-Fc conjugate.

Basal insulin therapy requires sustained and low-variability of insulin exposure; however, natural human insulin is rapidly cleared, thus necessitating frequent subcutaneous injections. Here we report a modular chemical platform for constructing monovalent insulin-Fc conjugates with structural homogeneity and long-term...