Wang-Fei Yang

Hydrophobic Patch Spacing Produces Nonmonotonic Compaction in Intrinsically Disordered Proteins

The conformational ensembles of intrinsically disordered proteins (IDPs) are encoded by the distribution of physicochemical interactions along their sequences. Although hydropathy-based descriptors capture average chain dimensions across diverse IDPs, the consequences of spacing localized hydrophobic patches remain poo...