Wangzheqi Zhang

Protein Post-Translational Modifications in the Regulation of Ferroptosis: New Opportunities and Challenges for Cancer Immunotherapy

Ferroptosis is an emerging form of programmed cell death driven by the excessive accumulation of iron-dependent lipid peroxides, which plays a pivotal regulatory role in suppressing tumor initiation and progression. In recent years, protein post-translational modification (PTM), as a core molecular mechanism regulating...

The interplay between chronic inflammation and tumorigenesis: unraveling the inflammation-driven axis.

Chronic inflammation is now recognized as an important factor linking tissue damage to the development of cancer. Epidemiological studies have suggested that 20%-25% of cancers are related to chronic inflammation, as exemplified by chronic hepatitis B infection inducing hepatocellular carcinoma (HCC) or Helicobacter py...

The cGAS-STING pathway: mechanistic basis, dual biological functions and translational therapeutic advances

Post-translational modifications in Neuroimmune cells during neuroinflammation: integrated regulatory networks and therapeutic opportunities

Neuroinflammation represents a common pathological mechanism underlying a wide range of central nervous system (CNS) disorders, encompassing neurodegenerative disorders (NDDs), ischemic stroke (IS), traumatic brain injury (TBI), and demyelinating diseases such as multiple sclerosis (MS). This process is initiated by th...