Wayne W. Harding

Hybrid Design Reveals a Dopamine D3R Ligand with Promising in vitro ADME Properties

There is significant interest in identifying dopamine D3 receptor (D3R) antagonists and partial agonists with favorable drug-like properties as in vivo chemical tools and as experimental therapeutics for substance use disorders. We hypothesized that preserving the classical D3R antagonist pharmacophore while incorporat...