Sinapine thiocyanate (ST) ameliorates endothelial cell dysfunction by targeting chloride intracellular channel 4 (CLIC4) to treat hypoxia-induced pulmonary hypertension.
BACKGROUND AND PURPOSE Sinapine thiocyanate (ST) has effects in treating respiratory diseases. Its action in hypoxic pulmonary hypertension (HPH) remains poorly understood. We evaluated the potential of ST on HPH and its molecular mechanism. EXPERIMENTAL APPROACH ST was evaluated on a rat model HPH. Single-cell RNA s...