Open access
Oct 2026
A fluctuation test for gastruloid heterogeneity.
Stem cells self-organize into models of early development, but even under carefully controlled conditions, the resulting organoids exhibit substantial "inter-individual" heterogeneity. To explore its origins, we generated monoclonal gastruloids, each derived from a single mouse embryonic stem cell (mESC). Molecular pro...
Samuel G. Regalado, Cheng-Xiang Qiu, Sanjay Kottapalli et al.
· Cell · 1 citation