Author

Wei Chen

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Open access Sep 2026

A cfDNA fragmentomics classifier for noninvasive differentiation of benign and malignant renal masses

Noninvasive differentiation of malignant and benign renal masses remains a major clinical challenge, particularly for radiologically indeterminate lesions. Here, we developed and validated a plasma cell-free DNA (cfDNA) fragmentomics-based machine learning classifier for renal mass characterization. The model was train...

Lin-Fei Li, Cong Wang, Song Wang et al. · Molecular Biomedicine · 0 citations

Jul 2026

Systematic Scanning Mutagenesis Unveils the Structure-Function Landscape Enabling Aptamer Evolution.

A structure-function landscape for aptamers is introduced, constructed by systematic single-point mutagenesis that maps the contribution of each nucleotide to target binding and highlights its potential to guide the development of high-performance biosensors.

Zhuoer Chen, Qi Sun, Xian-Lu Lei et al. · Analytical Chemistry · 0 citations

Review Jul 2026

Adsorption-stage phage biosensors for foodborne bacteria detection: mechanisms, engineering strategies, and perspectives.

The rapid and specific detection of foodborne bacteria in complex matrices remains a critical analytical challenge. Conventional nucleic acid amplification and immunological methods offer high analytical sensitivity, but they often provide limited information on bacterial viability because nucleic acids and antigenic e...

Xingying Mou, Xin-Ge Cui, Yongkang Zhang et al. · In Analysis · 0 citations