Author

Wei-Chen Yu

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Review Open access Aug 2026

Mitochondrial DNA in Tumor Evolution and Heterogeneity: Characteristics, Technological Advances, Applications and Challenges

Tumor heterogeneity and Darwinian evolution act as core drivers of therapeutic resistance. Deciphering the phylogenetic architecture of cancer demands high‐resolution lineage tracing. Nevertheless, exogenously introduced lineage markers possess inherent limitations. This review presents somatic mitochondrial DNA (mtD...

Zifeng Ruan, Zi-Hao Chen, Wei-Chen Yu et al. · MedComm - Oncology · 0 citations

Review Open access Aug 2026

Modulation of Inflammation-Driven Hepatocarcinogenesis: The Hepatic Immune Microenvironment, Gut–Liver Axis, and Neuroregulation

A deeper understanding of fundamental pathological mechanisms provides a conceptual framework for elucidating the initiation and progression of HCC and offers a theoretical basis for the future development of preventive and targeted therapeutic strategies, although the translation of these mechanistic insights into cli...

Wei-Chen Yu, Kai Yin, Chen-Na Liu et al. · Journal of Hepatocellular Ca... · 0 citations