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Author

Wei-Cheng Li

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Open access Oct 2026

Esketamine’s therapeutic effect on anhedonia in adolescents: a post-hoc of a randomized controlled trial

Anhedonia, a prominent symptom of major depressive disorder (MDD), severely impairs patients’ quality of life and is challenging to treat. Although esketamine has shown potential in treating anhedonia in adult treatment-resistant MDD, its effects on adolescents remain under-explored. In this study, a prosp...

Qian-Qian Wu, Wei-Cheng Li, Zhan-Jie Luo et al. · 0 citations
Aug 2026

Normative Modeling of sgACC-DLPFC Functional Connectivity Identifies a Personalized rTMS Target Associated with Clinical Response in Major Depressive Disorder.

The FCND-guided target framework provides a personalized, mechanism-informed strategy for precision neuromodulation in MDD and is statistically consistent with the hypothesis that distance influences improvement through Z-score normalization in the active group, with a directionally consistent trend in the iTBS dataset...

Zhan-Jie Luo, Wei-Cheng Li, Guanxi Liu et al. · 0 citations

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