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Wei-Chuan Shih

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Oct 2026

Multi-modal imaging-based biosensing platform for digital small extracellular vesicles profiling and cancer detection

Detecting the level of small extracellular vesicle (sEV) and their molecular contents digitally can potentially improve cancer detection. This potential has been hampered by insufficient sensitivity, dynamic range, and the need for purification and/or concentrating. We demonstrate a multi-modal imaging-based biosensing...

Wei-Chuan Shih · Enhanced Spectroscopies and... · 0 citations

Oct 2026

Plasmonic liquid biopsy for breast cancer detection via small extracellular vesicle counting in plasma

Small extracellular vesicles (sEVs, aka, exosomes) are potential biomarkers for breast cancer liquid biopsy, but their nanoscale size and the complexity of plasma make sensitive, reproducible, and scalable measurements challenging. Here we report plasmonic nano-aperture label-free imaging (PANORAMA) assay implemented o...

Abhay Kotnala, S. Mahmud, Omid Mohsen Daraei et al. · Plasmonics · 0 citations

Sep 2026

Isolation and Purification-Free Digital Single-Small Extracellular Vesicle Biosensing with Scalable Plasmonic Arrays.

Recent advances in plasmonic biosensing and imaging have enabled label-free analysis of single biological nanoparticles. We previously developed PlAsmonic NanOapeRture lAbel-free iMAging (PANORAMA) for isolation and purification-free, digital counting and precise localization of antibody captured, tetraspanin-positive...

Mohammad Sadman Mallick, Saswat Mohapatra, Abhay Kotnala et al. · ACS Sensors · 0 citations