Open access
Oct 2026
Genetic Modulation of ALT Leads to Underestimation of Liver Injury in Male ALDH2*2 Drinkers.
BACKGROUND & AIMS Serum alanine aminotransferase (ALT) is commonly used to detect hepatocellular injury. However, genetic and metabolic factors may modulate ALT levels. We focused on the potential impact of an in-activating mutation in aldehyde dehydrogenase 2 (ALDH2*2, rs671) polymorphism, prevalent among East Asians,...
Takuya Seike, Yi-Hsun Chen, Wei-Chung Chen et al.
· JHEP Reports · 0 citations