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Open access Sep 2026

Spatial, single-nucleus and pathological profiling of the invasive front in early hepatocellular carcinoma for characterizing specific leading-edge cell niche and improving recurrence modeling

The tumor leading edge (TLE) is a critical region where tumor cells interact with the microenvironment to drive invasion and metastasis; however, its cellular architecture in early hepatocellular carcinoma (HCC) remains poorly understood. Here, we integrated single-nucleus RNA-seq (snRNA-seq), spatial transcriptomics,...

Xi-Cheng Wang, Xiao-Lan Mu, Yong Fu et al. · 0 citations
Review Open access Aug 2026

Agentic systems in computational pathology: architectures, evidence, and translational challenges

This work reviews agentic systems in computational pathology using an operational taxonomy based on dynamic control flow, inference-time tool selection, and knowledge integration to emphasize validation scope, computational cost, workflow integration, hallucination and security risks, regulatory requirements, patient p...

Xin-Yu Lu, Qian-Kun Li, Yak Gao et al. · 1 citation

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