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Author

Wei-Dong Sun

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Review Sep 2026

Targeting Nicotinamide Metabolism to Reprogram the Tumor Microenvironment: Mechanisms and Novel Therapeutic Strategies.

This review examines how nicotinamide (NAM) metabolism may contribute to malignant remodeling of the TME at three interconnected levels: fueling the hypermetabolic state of cancer cells and contributing to TME acidification; modulating tumor angiogenesis; and establishing and sustaining an immunosuppressive, chronic in...

Wei-Dong Sun, Shuang-Zhou Bi, Xiao-Juan Zhu et al. · 0 citations
Review Aug 2026

NAMPT beyond NAD+ biosynthesis: roles in tumor microenvironment remodeling and cancer progression.

The multifaceted pro-tumorigenic mechanisms through which nicotinamide phosphoribosyltransferase (NAMPT) regulates key features of the TME, including macrophage polarization and immune responses, metabolic reprogramming and TME acidification, angiogenesis, and the maintenance of epithelial-mesenchymal transition and ca...

Wei-Dong Sun, Shuang-Zhou Bi, Xiao-Juan Zhu et al. · 0 citations

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