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Open access Aug 2026

Cell-inspired dual-tandem catalytic nanoreactors drive targeted hearing protection

Sensorineural hearing loss is driven by disruption of cochlear homeostasis, where dysregulated redox, ionic, and metabolic factors lead to hair cell degeneration and synaptic injury. Current strategies lack the capacity to restore the enzymatic clearance of reactive oxygen species or penetrate the blood-labyrinth barri...

Bao-Ying Xu, Xin-Rui Chen, Kai-Xuan Hu et al. · 0 citations
Sep 2026

Heavy‐Atom‐Engineered Conjugated Polymer Enables Thermosensitized Synergistic Cancer Phototherapy

Conjugated polymer‐based phototheranostics have attracted considerable attention for cancer treatment owing to their excellent photothermal properties and biocompatibility. However, integrating efficient photodynamic activity into conjugated polymer systems without compromising their intrinsic photothermal performanc...

Xiang-Mei Wen, Meng Chen, Xue-Yan Yao et al. · 0 citations
Aug 2026

Living Microbe-Driven Bioorthogonal Catalysts Enables Cytotoxin Generation, Cuproptosis and Lactate Depletion for Synergistic Tumor Therapy.

A living bacterial hybrid reactor is developed by integrating Shewanella oneidensis MR-1 with Cu(II)-based zeolitic imidazolate frameworks to enable metabolism-guided and tumor-confined bioorthogonal catalysis, overcoming key limitations of conventional bioorthogonal catalysis and enabling precise, tumor-confined thera...

Li-Li Xia, Xiangxuan Chao, Zitong Zhao et al. · 0 citations

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