Oct 2026
Stepwise engagement of cingulate ensembles underlies motivational decline in chronic pain.
Chronic pain can progress from sensory hypersensitivity to impaired motivation, but the underlying circuit mechanisms remain unclear. Using whole-brain activity-dependent tagging, projection-specific perturbations, in vivo Ca2+ imaging, and single-unit recordings in male mice, we identify stage-dependent engagement of...
Wen-Ying Xu, Jiu-Yang Sun, Chun-Guang Chu et al.
· Neuron · 0 citations